From the archives....
My .240 GNR varmint house rig. I was having problems with critters at night around the chicken house. The Coyotes or Bobcat was too elusive for me. But I was ready. I used 105 gr. bullets at HHC once planning for possible hog with the small caliber but later found the 85 gr. was a much better all round bullet for it. It affords higher velocity and a bit flatter trajectory if you needed it. 
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My .338 GNR Encore hunting rig. I used it at the Y-O for Blackbuck. (sucessfully - Doug too) The 200 gr. Hornady more conventional (and cheaper) bullets were giving me 100% expansion in the backstop with 2600 fps.  Very thick jackets for smaller game use. It's still a dandy caliber.
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John Ramsey Miller, the novelist, who tried his hand at a little Buffalo shooting with his Black Widow .410 GNR revolver. I think he had a 2X Burris on it.  They had a deal at HHC one year for a yearling at $995 all inclusive.  John took a high lung shot with a 255 gr. cast solid and was surprised that it didn't just fall over. We chased it for a while, mortally wounded of course, but those lungs are big. He shot it a couple times more too. The bullets shot through so fast it looked like he was missing. Debris flying up 50 yds. beyond after shooting right through. Placement, placement, placement. Perhaps a good jacketed bullet would have been a better choice, but he didn't know how big a buffalo. Gary advised a neck shot, JRM was trying to break down a shoulder and went high. Guide's advice.
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