My personal top Reeder Picks...
I have been blessed over the past couple decades to have sampled just about all of GNR's varied cartridges and most of his custom fare. What I do not of have not owned my fickle friend Doug took up the slack. We've about tried them all.
If you can handle it the .378 GNR is not only the largest flatter shooting GNR but a fantastic grab and go from Whitetails to Buffalo. I've come back home to this one. Years ago I had JD Jones' .375 JDJ which is a good number and about max for the Contender platform but the .378 GNR is a bunch more and has different thrust physics on the breachface, having a smaller area case head. If you know of a better one I'd like to hear about it.
Shot the Red Stag twice (110 yds.), just to be sure. 260 gr. Nosler at 2350 fps.
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A bang flop at 100 yds., 270 gr. Hornady at 2250 fps.
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Just under the .378 is the .366 cal. but it's so close as to be moot. The .338 GNR and 8mm are also close but shoot a little flatter and lighter bullets but both can perform well with 200 gr. The arguments as to which is best for who is truly subjective.
.338 GNR Blackbuck, 200 gr. Hornady at 100 yds. running 2600 fps from 14 + 2" Encore. Shot him twice, once, then again flopping around. A $2500 effort, couldn't risk losing him! Both bullets entered chest (3" apart) and came out under and between back legs (exits 4" apart), he was not going anywhere.
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Larger GNR's on the .348/.50 AK platform are .416/.440/.475 that I have. The .416 is a deluxe big/dangerous game round and not inexpensive to feed, but a little goes a long way anyway. The .440 is great being able to shoot any .44 bullet, the .475 can do pistol projectiles too. I never tried the .450 but know what it would do.
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One of my all time favorites for the G2/Contender platform is the 7mm GNR. The .30 GNR is very close but I just like 7mm bullets. Both are based on maximizing the .30-30 Win. case and can still shoot their parents 7x30 Waters and .30-30, fireforming cases in the process. They basically give you a pocket 7x57 and .30 Savage. I'm just a 7mm guy. Flat shooting and zero recoil, I love the braked versions. I'd not really be scared to try an Elk at my skill personal amateur level because I know I can hit well with it and the 7mm slugs will perform predictably.
I was using 120 gr. Nosler Ballistic Tips at a sedate 2400 fps. Not hot at all and so accurate. Always fully penetrates.
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There are so many arguable levels of the best GNR wheelgun rounds. Backed into a corner the .429 GNR has to be a winner for me. Not only is it a grand boost to the .44 Magnum but totally transformed in the single shot platform, nearing .444 Marlin rifle performance. The fact you can simply rechamber a Ruger Redhawk or Marlin 1894 is fantastic.
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*No you can't shoot the pointy tips in a revolver. They stick out. You can pull them out with pliers or grind flush. Fine in the single shot.
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The .410 GNR is so close it's up to you. I like the varied .44 bullets myself. I chose to play with the .41 GNR on smaller 6-shot platforms. It's is a dandy too to not get too close to an overlap.
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There are many others, but of them all, these represent some of my favorites and are keepers in my battery.